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STEROID 17-ALPHA-HYDROXYLASE
Descriptors Found:
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DeCS
Descriptor
English
:
Steroid 17-alpha-Hydroxylase
Descriptor
Spanish
:
Esteroide 17-alfa-Hidroxilasa
Descriptor
Portuguese
:
Esteróide 17-alfa-Hidroxilase
Synonyms
English
:
17 alpha-Hydroxylase
17,20-Lyase
CYP17
Cytochrome P-450(17 alpha)
P450(c17)
Steroid 17 alpha-Monooxygenase
Steroid 17-Hydroxylase
Steroid 17-Monooxygenase
Tree Number:
D08.244.453.915.748
D08.811.682.690.708.170.915.748
D08.811.682.690.708.783.745
D12.776.422.220.453.915.748
Definition
English
:
A microsomal cytochrome P450 enzyme that catalyzes the 17-alpha-hydroxylation of
progesterone
or
pregnenolone
and subsequent cleavage of the residual two carbons at C17 in the presence of molecular
oxygen
and
NADPH-FERRIHEMOPROTEIN REDUCTASE
. This enzyme, encoded by CYP17 gene, generates precursors for glucocorticoid, androgen, and estrogen synthesis. Defects in CYP17 gene cause congenital adrenal
hyperplasia
(ADRENAL
HYPERPLASIA
, CONGENITAL) and abnormal sexual differentiation.
Entry Combination - descr/qualif
English
:
Steroid 17-alpha-Hydroxylase
/
deficiency
use
Adrenal Hyperplasia, Congenital
See Related
English
:
Adrenal Hyperplasia, Congenital
History Note
English
:
2003 (1978)
Allowable Qualifiers
English
:
administration & dosage
adverse effects
antagonists & inhibitors
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
drug effects
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
pharmacokinetics
poisoning
radiation effects
supply & distribution
secretion
standards
toxicity
therapeutic use
ultrastructure
urine
Record Number:
23464
Unique Identifier:
D013254
Occurrence in VHL
:
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